Bisphosphonates

Bisphosphonates are medicines used to treat osteoporosis and other bone conditions. They help to slow down bone loss and reduce the risk of fractures, especially in the spine and hip.

Why Are Bisphosphonates Used?

Osteoporosis causes bones to become weak and fragile, increasing the risk of fractures even with normal activity.
Bisphosphonates help slow bone loss and reduce the risk of fractures in conditions like osteoporosis and Paget’s disease.

How Do They Work?

Bone naturally breaks down and reforms. Bisphosphonates slow the breakdown, allowing bone density to improve and reducing fracture risk over time.

Forms of Bisphosphonates

Oral Bisphosphonates: Taken once weekly (e.g., alendronate 70 mg) or once monthly (e.g., ibandronate), depending on your doctor’s prescription.
Intravenous (IV) Bisphosphonates: Given as an infusion, typically once yearly

Benefits You Can Expect

Over time, bisphosphonates reduce the risk of spine and hip fractures.
They help protect bone health, especially when your bones are most vulnerable.

How to Take Bisphosphonates Safely

Oral Bisphosphonates:
- Take first thing in the morning, on an empty stomach, with a full glass of water.
- Wait 30 minutes (up to 1 hour) before eating, drinking, or taking other medicines.
- Remain upright (sitting or standing) during this time.
IV Bisphosphonates:
- Administered in clinic or hospital—your doctor will schedule these doses.
Additional Supplements:
- Bisphosphonates work best with calcium and vitamin D to help strengthen bones.

Precautions & What to Watch For

Stomach upset or heartburn is common—taking the medication correctly helps prevent this.
Always inform your dentist if you are taking bisphosphonates before any dental procedures.
Your doctor will monitor your treatment and may pause bisphosphonates after 3–5 years depending on your fracture risk.

Key Reminders

Bisphosphonates slow bone loss and reduce fracture risk.
Take oral bisphosphonates as instructed: morning, empty stomach, with water, and stay upright.
Always use them together with calcium and vitamin D unless advised otherwise.
IV options are available if oral is not suitable.
Inform your dentist before any dental work if you are taking bisphosphonates.
Your doctor may review and adjust treatment after 3–5 years based on your bone health.

Further Reference

Adapted from the Australian Rheumatology Association (ARA) Patient Information on Bisphosphonates.